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KMID : 1004820080090020047
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Journal of Biomedical Research
2008 Volume.9 No. 2 p.47 ~ p.54
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Acute and Subacute Toxicity of Copper Sulfate in the Zebrafish(Brachydanio rerio)
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Lee Je-Yeop
Heo Gang-Joon
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Abstract
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The acute and subacute toxicities of copper sulfate were evaluated in zebrafish (Brachydanio rerio). Dipping of fishes for acute toxicity was performed for a period of 24 h, and TLm24h value (median tolerance limit = LC50) was 1.36 ppm. Clubbing of gill filaments due to severe epithelial hyperplasia of gill lamella were observed. And epithelial edema, fusion and necrosis of renal tubules were presented. The most significant change was mild epithelial hyperplasia of gill lamella in subacute toxicity test which fishes were exposed to 0.15 ppm of copper sulfate for 1 week.
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KEYWORD
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copper sulfate, toxicity, zebrafish, TLm24h
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